USING AN ORGANOTYPIC MODEL OF TEMPORAL LOBE EPILEPSY (TLE) TO INVESTIGATE THE ROLE OF GABAERGIC RECEPTORS ON SEIZURE SUPPRESSION AND STRUCTURAL REMODELING IN THE MOUSE HIPPOCAMPUS

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Live Poster Session: Zoom Link
Thursday, July 30th 1:15-2:30pm EDT

Fitzroy 'Pablo' Wickham
Fitzroy ‘Pablo’ Wickham

Fitzroy ‘Pablo’ Wickham is a Jamaican-born Wesleyan undergraduate double majoring in Neuroscience and Theatre with a minor in Chemistry. He is a research assistant in the Naegele Lab at the Wesleyan University conducting stem cell research to treat temporal lobe epilepsy in mice. On campus, he also serves as a Head Resident for Residential Life, Senior Class President, Honor Board/Community Standards Board member and is also involved in the Basal Gang, Wesleyan Minority Association of Premedical Students (WesMAPS), student theatre and the Jamaican Heritage Club, YAADI. His aspirations are to become a neurosurgeon, researcher and actor.

Abstract: Seizures are described as sudden, uncontrollable electrical disturbances in the brain brought on by high-frequency synchronous neural activity. In temporal lobe epilepsy (TLE), many patients experience focal seizures in the temporal lobes of the brain. Research in the Naegele lab investigates stem cell therapies for TLE– an alternative to drug and surgical treatments. In the present study, we present an organotypic slice culture model of TLE from the postnatal mouse hippocampus. Spontaneous seizure activity will be studied in this in vitro model over time and the effect of GABAergic progenitor transplants on structural remodeling in these hippocampal slices to induce seizure suppression will be investigated using pharmacological interventions.

CISPosterSession_Pablo_NaegeleLab_V5

Live Poster Session: Zoom Link
Thursday, July 30th 1:15-2:30pm EDT

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